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Dr Chris Hanley

 BSc, MRes, PhD
Associate Professor

Research interests

  • Tumour microenvironment
  • Fibroblasts and the Extracellular Matrix
  • Quantitative Cell Biology

More research

Accepting applications from PhD students.

Connect with Chris

Email: C.J.Hanley@soton.ac.uk

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About Research Publications Supervision Teaching External roles and responsibilities Biography
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About

Chris Hanley graduated from Imperial College London with a Biochemistry BSc in 2008. This was followed by an MRes (2011) and PhD (2014) in cancer research from the 黑料社, including a period of study at the University of Wisconsin-Madison. Following his PhD, Chris has worked as a post-doctoral researcher at the 黑料社 Cancer Sciences Unit and at the Johns Hopkins Centre for Cell Dynamics.

Dr. Hanley鈥檚 research aims to understand how the tumour microenvironment influences cancer progression. Particularly focussing on the the role of cancer associated fibroblasts (CAFs). To examine these processes, state-of-the-art methods for analysing human tissue samples are used: including single-cell (sc)RNA-Sequencing; digital pathology analysis of multiplexed immunostaining and 3D organotypic co-cultures that incorporate autologous tumour organoids and stromal cells.

A significant achievement in this work was the identification of NAD(P)H Oxidase 4 (NOX4) as a therapeutic target.  Following this discovery, the use of NOX inhibitors to treat cancers has been patented (Hanley. CJ co-inventor - WO2019086579) and clinical trials are in development to test NOX4 inhibitor efficacy in cancer.

Qualifications

BSc, Imperial College London 2008

MRes, 黑料社 2011

PhD, 黑料社 2014

 

 

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